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The Gerontologist, Volume 55, Issue Suppl_2, November 2015, Pages 384–385, https://doi.org/10.1093/geront/gnv177.06
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23 October 2015
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PUERARIA LOBATA, A POTENTIAL ANTI-AGING FOOD, The Gerontologist, Volume 55, Issue Suppl_2, November 2015, Pages 384–385, https://doi.org/10.1093/geront/gnv177.06
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S. Quan 1 , J. Lin 1 , C. Zhang 2 , X. Xia 1 , J. Si 1 , 1. Sir Run Run Shaw Hospital, Institute of Gastroenterology, Zhejiang University, Hangzhou, China,2. Department of Clinical Medicine, Zhejiang University City College, Hangzhou, China
Objective: To explore the anti-aging effects of puerarin (the main constituent of Pueraria lobate) in miceMethods: 60 C57BL6 mice were randomly divided into five equal groups: control group (administered with physiological saline for 7 weeks), model group (subcutaneously injected with D-galactose at the dose of 150 mg /kg.d for 7 weeks), puerarin groups (administrated by intraperitoneal injection with three different doses for 4 weeks from the fourth week based on the model group). Result: 1SA-β-gal positive rate and expression of P53/P21WAF1, p16INK4a increased in model group(P<0.01). 2Interleukin-6 (IL-6) increased, superoxide dismutase (SOD) decreased in peripheral blood of model group(P<0.05). 3Administration of puerarin for 4-weeks significantly reversed the biochemical markers mentioned above in a dose-dependent manner(P<0.05). Conclusion: Puerarin has protective effects on senescent mice and Pueraria Lobata could be an anti-aging food.Key words: Puerarin, Anti-aging, D-galactose, Biochemical markers,
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